In a study recently published in Nature Communications, the research groups of Professor Hung-Yuan Ji (Graduate Institute of Biochemical Sciences, NTU), Professor Hong-Wen Lee (Department of Chemistry, NTU), and Professor Mara Prentiss (Department of Physics, Harvard University) demonstrated that a protein complex called Hop2-Mnd1 not only stimulates but also selectively suppresses the DNA recombinase Dmc1—depending on the degree of sequence similarity between DNA strands.