Unlike animals, plants lack an adaptive immune system and instead rely on RNA silencing to defend against viruses. In response, viruses have evolved suppressors to counter this pathway.

Prof. Shih-Shun Lin at National Taiwan University has long studied the viral suppressor HC-Pro. In a recent Nature Communications paper, his team reveals that HC-Pro blocks HEN1 methyltransferase activity and induces autophagy to degrade AGO1, key components of RNA silencing, effectively disarming the plant’s antiviral defense.

While HC-Pro’s role as a suppressor is well known, this study uncovers a novel mechanism, challenging established views and marking a significant advance in plant virology. The work highlights the value of persistence, rigorous experimentation, and creative thinking.

This discovery is expected to inspire new directions in fundamental plant research and aid in the development of virus-resistant crops.

“No matter how great the challenges, as long as we hold on to our faith and original intention, we will eventually see the light and hope on the path of scientific pursuit,” said Prof. Shih-Shun Lin.